Pogba gave another under-par performance against West Ham but he was not the only player to disappoint in the late September sunshine.
And here are the best moments of the game in pictures.
Manchester United´s David de Gea looks dejected after West Ham´s third goal.
The Evening Standard also believe Mourinho is exhausted of Sanchez's spluttering displays, with their report stating Mourinho has been "particularly incensed by the 29-year-old forward for his overall performance levels since the start of the season". It is the worst start to a season for the Red Devils since 1989/90.
And it was another tough day at the office for him, summed up by him passing the blame in his post-match press conference.
West Ham largely nullified the threat of Romelu Lukaku, who normally torments the Hammers. Manuel Pellegrini's side were rarely in trouble and doubled their lead when Andriy Yarmolenko's shot looped in off Victor Lindelof in the 43rd minute.
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But what he got only intensified the sense that something is broken at Old Trafford and he does not have the tact to find the solution.
McTominay was making his first Premier League start of the season, having impressed Mourinho last term, and the 21-year-old midfielder was commended again by his manager.
The France global was stripped of his captaincy and had a awful game until he was substituted in the second-half.
The contrast with Manchester City could not be more marked, with Pep Guardiola's high rollers brushing aside the limited challenge of Brighton with goals from Raheem Sterling and Sergio Aguero, who linked superbly with the Englishman to net his seventh goal in all competitions this season.
But the sense of hope did not last long as Arnautovic held his nerve to steer the ball past De Gea after a through ball from West Ham captain Mark Noble. But the Austrian is back in full form. [In the League Cup against Derby County] The goal would be disallowed.
Shaw's gesture was certainly appreciated by the United away fans, who had very little to cheer about at the London Stadium.
Everyone is playing for the badge and this is summed up by this picture.
Most importantly of all, West Ham are showing great team spirit.