But while City begin the campaign as firm favourites after their record-breaking title campaign last season, they will be well aware of the threat posed by Juergen Klopp's improving Liverpool and the rest of the big six.
The dynamic Alex Oxlade-Chamberlain, in theory, is another contender but considering he's recovering from a serious knee injury, will likely not be in action till the end of the 2018/19 season at the earliest.
Karius made his first appearance at Anfield since a blundering display in the Champions League final during Tuesday's 3-1 win over the Serie A side.
It has been clear to see that the World Cup victor has been a target all summer long and was close to signing in June, only for the deal to fall through, apparently due to pre-historic medical conditions concerning a knee ligament operation back in 2015.
Thibaut Courtois could leave Chelsea in the coming days, admits Maurizio Sarri
Chelsea have signed just one player this summer who is likely to be directly involved in the first-team - that's Jorginho . Eden Hazard has sought permission from Maurizio Sarri to report for duty at Chelsea a day later than scheduled.
"He had to learn kind of a new position for him. I have no clue in the moment what we will do at the weekend".
"He was very comfortable on the ball five minutes in and it meant we could show for it and he was starting most of our play, so it was a very good performance from him, but overall the squad performed very well today".
Naby Keita will help to further bolster Klopp's midfield after his £48m move to Liverpool FC from Bundesliga side RB Leipzig.
"He said: "[I'm] not sure, don't know - we have to see how he reacts. "If things were fixed with just one line-up and all the others were only needed when the rest are ill that would be the wrong way and we'd have no chance".
With attacking trio Sadio Mane, Roberto Firmino and Mo Salah fit and raring to go ahead of the league opener against West Ham, Klopp's pre-season plans are falling into place, with Jordan Henderson having returned after his World Cup heroics with England last month.