A bomb explosion has killed scores of people at the Mubi main market in Adamawa State.
No group has claimed responsibility for Tuesday's carnage but many believe Boko Haram to be behind it.
In recent months, Boko Haram activity has been concentrated in the far north of Adamawa state, around Madagali, near the border with Borno state.
Boko Haram briefly took over Mubi in late 2014 as its fighters rampaged across northeast Nigeria, seizing towns and villages in its quest to establish a hard-line Islamic state.
The Nigerian government had said since December 2015 that Boko Haram has been defeated.
Nigerian President Muhammadu Buhari has been in the United States this week and met his U.S. counterpart Donald Trump, who pledged more support in the fight against Boko Haram.
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Trump indicated a further order for attack helicopters was also in the pipeline. "Our special gratitude to all the rescue workers & medical personnel who attended to victims".
"People were heading to the mosque for prayers when the suicide bomber struck", said the official who preferred to be anonymous.
He detonated his explosives "five minutes before the prayer started", he added.
In a tweet on its handle, the presidency wrote: "Today's suicide bomb attacks in Mubi, Adamawa State, targeting a Mosque and Market, are tragic & despicable".
In October 2012, at least 40 people were killed in an attack on student housing in Mubi that was widely blamed on Boko Haram. In November, a teenage suicide bomber attacked worshippers as they gathered for morning prayers, killing at least 50 people in one of the region's deadliest assaults in years.