However, the 24-year-old required lengthy treatment from the Liverpool medical team after suffering a knee injury while tackling Aleksandar Kolarov in the 18th minute.
Liverpool manager Juergen Klopp said it was "probably a really bad injury" and acknowledged that Oxlade-Chamberlain's season was over, even before he has undergone any scans to assess the damage.
Liverpool and England midfielder Alex Oxlade-Chamberlain's hopes of heading to the World Cup are in doubt after he suffered a what appeared to be a serious injury in the 5-2 win over AS Roma in their Champions League semi-final, first leg on Tuesday.
"If we can say that already before the scan, that's never good news so that means for us it's a massive blow, of course". Oxlade-Chamberlain could also be in danger of missing out on the World Cup in June.
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Georginio Wijnaldum, who replaced Oxlade-Chamberlain during the tie, said: "I just spoke with him in the dressing room and what the manager said is hard". "That is bad news for us".
"We all know, the best thing, if you go direct to final, semifinals and have important games in [the domestic] league you need a full squad", Klopp said.
And it looks like Oxlade-Chamberlain's spot in Gareth Southgate's England squad could be in jeopardy if the prognosis comes back as negative.
Trent Alexander-Arnold added: "Obviously we're all gutted for him".