Cosby's lawyers launched a scathing attack on his accuser, and prosecutors put the first in a parade of women on the stand to portray the comedian as a sexual predator. "She's unconscious. She's out of it", Steele said.
She is one of 50 women who have accused him of sexual molestation.
The remarks came the day the prosecution began to call witnesses, including one woman who testified that Cosby sexually assaulted her 34 years ago.
A lawyer who represented Constand in the civil case, Dolores M. Troiani, rejected Mesereau's characterization of her client, calling it a "disgrace" that the legal system permits such defenses which, she said, deter women from coming forward to report sexual assault.
A previous trial on these charges ended past year in a hung jury and a mistrial. Ahead of opening statements, a topless protester who appeared on several episodes of "The Cosby Show" as a child jumped a barricade and got within a few feet of Cosby as the comedian entered the courthouse.
According to what the attorney told the jury, when Jackson asked Constand if she'd actually been assaulted or if it was just her plan to say that she was, Constand allegedly told her, "No, but I can say I was and set up a celebrity and get a lot of money for my education and my business".
"She has a history of financial problems until she hits the jackpot with Bill Cosby", Mesereau added.
She said she awoke on a bed fully clothed, while Cosby was naked.
He said Constand went to Cosby's home at least a half-dozen times and sneaked into bed with him at a CT casino, winning his trust so she could set him up later, he said.
Cosby's legal team at his first trial wasn't almost as aggressive in attacking Constand, focusing instead on inconsistencies in her statements to police and arguing the pair had a romantic relationship.
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Mr Cosby (80) faces three counts of aggravated indecent assault, each punishable by up to 10 years in prison.
"If you are not interested, why do you keep going back and back and back and back?"
The first witness in the case was Dr. Barbara Ziv, a forensic psychiatrist who testified about how sexual assault victims behave.
Cosby betrayed that trust in January 2004 when he pushed her to take drugs and wine that incapacitated her and then sexually assaulted her without her consent, prosecutors said.
Mesereau said that the defense had evidence that Constand had unpaid bills during her time at Temple, was struggling at her job and that they would produce emails showing she was running a "pyramid scheme" at the university.
Under no such constraints this time, the defense let loose on Constand.
"He was lonely and troubled and he made a bad mistake confiding in her what was going on his life", Mesereau said. Now prosecutors are glossing over myriad inconsistencies in Constand's story to pursue a criminal case.
In 2015, a judge made parts of that settlement public, including Cosby's deposition in which he admitted he got prescription sedatives to give to women with whom he wanted to have sex. When prosecutors declined to bring charges, she brought a lawsuit against him.
The prosecution's opening statement was delayed until Monday afternoon due to a defense motion to dismiss a juror. After questioning all 12 jurors and six alternates behind closed doors, Judge Steven O'Neill ruled the juror could stay, saying all the panelists told him they stuck to their pledge to remain fair and impartial.