Ally of the Syrian regime it helps militarily, Russia on Saturday called all parties to "restraint" and considered "absolutely unacceptable" to endanger the lives of Russian soldiers present in Syria. "We agreed that the coordination between our militaries will continue".
Iran's expanding clout during the war, including deployments of Iran-backed forces like Lebanon's Hizbollah near the Golan frontier, has raised alarm in Israel, which has said it would act against any threat from its regional arch-enemy, Teheran.
In its statement Saturday, Hezbollah said the "brave confrontation of the aggressing Israeli planes", including downing an F-16, ushers in a "new strategic phase" that puts an end to the violation of Syrian airspace and territories.
Iran's involvement in Syria in support of President Bashar Assad in a almost seven-year-old civil war - including the deployment of Iran-backed forces near the Israeli-occupied Golan Heights - has alarmed Israel, which has said it would counter any threat. "To cover their crimes in the region, Israeli officials are resorting to lies against other countries", foreign ministry spokesman Bahram Ghasemi told AFP.
A military statement said in Tel Aviv that twelve targets, including three Syrian aerial defence batteries and four other targets that are part of Iran's military establishment in Syria were attacked.
The Israeli army shot down an Iranian drone launched from Syria and struck a number of Iranian targets in the war-torn country, according to the Israeli military.
Israeli military said it was "monitoring events" and was "fully prepared for further action". "Today's developments mean the old equations have categorically ended", the heavily-armed movement said in a statement. "This is a complete operational success, both at the stage of interception of an unmanned aerial vehicle, and when suppressing sources of fire, as well as during subsequent retaliatory actions", Bar said as quoted by the Israel Defense Forces (IDF) press service.
Israeli F-16 fighter jets attacked Iranian sites inside Syria. The Syrian Observatory for Human Rights, a Britain-based monitor of the seven-year civil war, said the earlier Israeli raids had targeted several military bases in the east of the central province of Homs.
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With the downing of the first Israeli aircraft in over a decade, the rules of the game have changed on Israel's northern border.
The military says it has the drone in its possession.
The senior commander said the Zionist regime has been created by the USA and the United Kingdom, adding the Islamic Republic of Iran began to inflict heavy blows on the U.S. since early years of the Islamic Revolution.
The Israeli military declined to comment.
The sirens sounded in the Golan Heights are a result of Syrian anti-aircraft missiles, said the Israeli army in the statement.
Syria said its air defences repelled two Israeli raids on its military bases in the centre of the country, hitting more than one warplane during the first.
A picture taken in the northern Israeli kibbutz of Harduf on February 10, 2018, shows the remains of an F-16 that crashed after coming under fire by Syrian air defenses.
A second pilot was lightly injured while abandoning the aircraft.