Lions: Stafford, with a lot of tape covering his right cleat, stayed in the game after hurting his right ankle on his second touchdown when DT Tom Johnson fell on him.
Lions defensive end Ezekiel Ansah, in the last year of his contract, had three sacks for the second straight week to give him 12 this season and 44 in his five-year career.
The Packers finish the season 7-9, missing the playoffs for the first time since 2008. That score stood at the initial break.
Geronimo Allison caught 2-of-3 targets for 15 yards in the Packers' Week 17 loss to the Lions.
3 children killed in crash in southwest Missouri, troopers say
A highway patrol report says a tractor trailer struck a vehicle causing it to lose control and cross the center line. Another vehicle also going eastbound hit the Traverse, which made it run off the roadway and overturn.
With Roberts out, Hakeem Valles will serve as the Lions No. 3 tight end on Sunday against the Packers.
It may be a meaningless final game of the regular season for the Detroit Lions but that does not mean it's ok to just skip out on team meetings.
The second half saw more back-and-forth possessions until the Lions increased the gap to 27-3 on a 71-yard scoring strike from Stafford to Golden Tate at the 1:38 juncture of the third.
Brett Hundley threw 17-yard TD pass and 2-point conversion to Randall Cobb to pull the Packers within 16 early in the fourth period. He came into Sunday ranked fourth in the National Football League in passing yards, tied for seventh in passing touchdowns and eighth in quarterback rating.
The Lions (9-7) finished with a winning record in consecutive seasons for the first time since doing it three years in a row from 1993-95.